TLR 3 downregulates expression of schizophrenia gene Disc1 via MYD 88 to control neuronal morphology
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TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology
Viral infection during fetal or neonatal stages increases the risk of developing neuropsychiatric disorders such as schizophrenia and autism spectrum disorders. Although neurons express several key regulators of innate immunity, the role of neuronal innate immunity in psychiatric disorders is still unclear. Using cultured neurons and in vivo mouse brain studies, we show here that Toll-like rece...
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DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and CD27+ memory B cells were severely reduced in DOCK8-deficient 15H.H.J. and D.R.M. contributed equally to this work. AUTHOR CONTRIBUTIONS H.H.J., D.R.M., E.J, M.J.M., N.R., A.B., I.R., H.B., and M.R. performed the experiments. L.S., S.B, R.W., G.D., M.D., W.A., I.B., S.B., N.K., H.O., A....
متن کاملDOCK 8 Functions as an Adaptor that Links TLR – MyD 88 Signaling to B
DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and CD27+ memory B cells were severely reduced in DOCK8-deficient 15H.H.J. and D.R.M. contributed equally to this work. AUTHOR CONTRIBUTIONS H.H.J., D.R.M., E.J, M.J.M., N.R., A.B., I.R., H.B., and M.R. performed the experiments. L.S., S.B, R.W., G.D., M.D., W.A., I.B., S.B., N.K., H.O., A....
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The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 13 3159-3171 www.jem.org/cgi/doi/10.1084/jem.20081298 3159 The regulation of blood vessel size is closely coordinated to changes in blood fl ow. Initial variations in blood fl ow elicit reversible vasomotor responses, whereas sustained alterations in hemodynamic forces result in permanent structural changes aff ecting vessel exte...
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Abstract Background: The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome position 1q42, was initially identified at the breakpoint of a balanced translocation, t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large Scottish family. Methods: Our samples included 200 unrelated patients diagnosed with Schizophrenia on the basis of DSM-IV criteria an...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2016
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201642586